Viji Shridhar Selected Research

PFK158

10/2022	PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM.
1/2022	PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma.
6/2021	Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization.
1/2021	Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer.
1/2019	Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers.
1/2019	PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses.

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Viji Shridhar Research Topics

Disease

63	Neoplasms (Cancer) 01/2022 - 01/2002
38	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 01/2003
12	Carcinogenesis 01/2022 - 06/2006
11	Neoplasm Metastasis (Metastasis) 01/2022 - 05/2011
9	Carcinoma (Carcinomatosis) 01/2018 - 06/2003
7	Endometrial Neoplasms (Endometrial Cancer) 01/2020 - 02/2011
6	Ascites 06/2021 - 10/2012
6	Breast Neoplasms (Breast Cancer) 01/2021 - 05/2007
4	Hypoxia (Hypoxemia) 03/2013 - 03/2011
3	Mesothelioma 01/2021 - 10/2006
3	Lung Neoplasms (Lung Cancer) 10/2014 - 01/2010
3	Ovarian Epithelial Carcinoma 06/2014 - 03/2005
3	Hepatocellular Carcinoma (Hepatoma) 06/2009 - 01/2004
2	Malignant Mesothelioma 01/2019 - 08/2008
2	Disease Progression 03/2013 - 10/2012
2	Stomach Neoplasms (Stomach Cancer) 04/2011 - 07/2006
1	Tics (Tic) 10/2022
1	Glioblastoma (Glioblastoma Multiforme) 01/2022
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022
1	Melanoma (Melanoma, Malignant) 01/2022
1	Sarcoma (Soft Tissue Sarcoma) 01/2022
1	Leiomyosarcoma 01/2020
1	Inflammation (Inflammations) 01/2016
1	Demyelinating Diseases (Demyelinating Disease) 01/2016
1	Central Nervous System Diseases (CNS Diseases) 01/2016
1	Hyperglycemia 09/2015
1	Weight Loss (Weight Reduction) 09/2015
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2015

Drug/Important Bio-Agent (IBA)

13	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 07/2006
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2005
9	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017 - 06/2003
7	Quinacrine (Mepacrine)IBA 09/2021 - 11/2015
7	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2010
7	Heparin (Liquaemin)FDA LinkGeneric 01/2017 - 06/2003
7	SulfatasesIBA 01/2014 - 01/2004
7	Serine Proteases (Serine Protease)IBA 03/2012 - 02/2004
6	PFK158IBA 10/2022 - 01/2019
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2009
6	Carboplatin (JM8)FDA LinkGeneric 06/2021 - 11/2014
6	Paclitaxel (Taxol)FDA LinkGeneric 01/2020 - 03/2005
5	Small Interfering RNA (siRNA)IBA 01/2022 - 12/2008
5	PlatinumIBA 06/2021 - 03/2005
5	High-Temperature Requirement A Serine Peptidase 1IBA 02/2011 - 07/2006
5	Complementary DNA (cDNA)IBA 02/2011 - 03/2005
4	EnzymesIBA 01/2022 - 06/2003
4	RNA (Ribonucleic Acid)IBA 01/2019 - 05/2007
4	Metformin (Glucophage)FDA LinkGeneric 09/2015 - 05/2011
3	Antimalarials (Antimalarial Agents)IBA 04/2021 - 01/2017
3	Phosphotransferases (Kinase)IBA 01/2021 - 06/2003
3	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 08/2012
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2015 - 03/2013
3	Transcription Factors (Transcription Factor)IBA 10/2014 - 06/2009
3	Messenger RNA (mRNA)IBA 06/2014 - 10/2005
3	Biological ProductsIBA 06/2014 - 10/2006
3	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 01/2014 - 06/2003
2	Immunoconjugates (Immunoconjugate)IBA 01/2022 - 01/2022
2	Pharmaceutical PreparationsIBA 09/2021 - 10/2006
2	FructoseIBA 01/2021 - 01/2019
2	ChromatinIBA 01/2021 - 03/2011
2	Heparitin Sulfate (Heparan Sulfate)IBA 09/2019 - 03/2015
2	Gemcitabine FDA Link 09/2019 - 03/2015
2	CateninsIBA 09/2019 - 03/2015
2	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2019
2	Bevacizumab (Avastin)FDA Link 07/2017 - 10/2014
2	Sulfates (Sulfates, Inorganic)IBA 01/2017 - 03/2012
2	heparanaseIBA 03/2015 - 01/2014
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 03/2011 - 06/2003
2	Peptide Hydrolases (Proteases)FDA Link 02/2011 - 04/2010
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 05/2007 - 06/2003
2	ErbB Receptors (EGF Receptor)IBA 05/2007 - 10/2006
1	IntegrinsIBA 01/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2022
1	Leucine (L-Leucine)FDA Link 01/2022
1	Phospholipases A2 (Phospholipase A2)IBA 06/2021
1	Secretory Phospholipases A2IBA 06/2021
1	Phospholipases (Phospholipase)IBA 06/2021
1	Cathepsin LIBA 04/2021
1	Pemetrexed (MTA)FDA Link 01/2021
1	Antineoplastic Agents (Antineoplastics)IBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2020
1	GlycolipidsIBA 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2019
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2019
1	NucleotidesIBA 01/2018
1	arachidonyltrifluoromethaneIBA 01/2017
1	LipidsIBA 01/2017
1	CytokinesIBA 01/2016
1	AMP-Activated Protein KinasesIBA 01/2016
1	Interleukin-23 (Interleukin 23)IBA 01/2016
1	Interleukin-17 (Interleukin 17)IBA 01/2016
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 11/2014
1	nutlin 3IBA 11/2014
1	Thiostrepton (Gargon)IBA 11/2014

Therapy/Procedure

18	Drug Therapy (Chemotherapy) 06/2021 - 03/2005
7	Therapeutics 01/2022 - 06/2009
2	Menstrual Hygiene Products (Menstrual Pad) 01/2020 - 04/2015
2	Combination Drug Therapy (Combination Chemotherapy) 04/2011 - 03/2005
1	Hysterectomy 01/2020
1	TP protocol 05/2015
1	Subcutaneous Injections 10/2014